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. 2018 Jun 15;16:67. doi: 10.1186/s12915-018-0534-3

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© Weinkove et al. 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Folic acid shortens C. elegans lifespan via an E. coli abgT-dependent route during adulthood. Mean lifespan of glp-4(bn2) C. elegans maintained from day 1 of adulthood on WT (a only), ΔpabA, ΔabgT ΔpabA or ΔpabA (abgT OE) mutant E. coli with supplementation of (a) folic acid, (b) PABA-glu and (c) PABA. Error bars represent standard error. Asterisks denote the Log-rank non-parametric statistical test of survival, where ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, compared to lifespan on the non-supplemented condition of the same strain. Full lifespan data in Additional file 1: Table S1