Table 1.

Liver involvement as a poor prognostic factor in different therapeutic studies

Author	Treatment	N	Liver involvement	Median survival (months)	5-year survival	p values
Chamberlain (2000) [46]	Surgical resection	85	0–25%	–	90%
			25–50%	–	83%
			50–75%	47	80%
			> 75%	24	–
Yao (2001) [47]	Surgical resection	16	≤4 liver metastases	46	–	<  0.05
			> 4 liver metastases	20	–
Gupta (2005) [48]	TAE or TACE	123	0–25%	86	–
			25–50%	30	–	<  0.10
			50–75%	39	–	<  0.17
			> 75%	20	–	<  0.05
Kwekkeboom (2008) [14]	PRRT	310	None	> 48	–
			Moderate	> 48	–
			Extensive	25	–	<  0.01

Legend: TAE transarterial (bland) embolization, TACE transarterial chemoembolization, PRRT peptide receptor radionuclide therapy