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. 2018 Mar 22;19(9):940–948. doi: 10.1002/cbic.201700621

Scheme 1.

Scheme 1

Reactions of SDRs in specialized metabolism. A) Previously identified SDRs in specialized metabolism include iridoid synthase (ISY), tropinone reductases I and II (TRI and TRII), salutaridine reductase (SalR), menthone reductase (MNMR) and progesterone 5‐β‐reductase (PβR). B) Strictosidine aglycone is a central biosynthetic intermediate of MIA biosynthesis that can undergo reduction to form various alkaloid backbones. THAS1 and GS are previously discovered medium‐chain alcohol dehydrogenases.