Table 2.
Multivariable adjusted hazard ratios for overall mortality by pre-diagnostic lipids and breast cancer molecular subtypes
| All cases (eventsa=129) | Luminal A (eventsa=45) | Luminal B (eventsa=29) | HER2-enriched (eventsa=17) | TNBC (eventsa=38) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | |
| Triglycerides | ||||||||||
| Continuous, mmol/l | 464 | 1.01 (0.88–1.22) | 228 | 0.99 (0.56–1.75) | 99 | 1.64 (0.78–3.46) | 43 | 0.06 (0.01–0.77) | 94 | 1.02 (0.83–1.24) |
| Tertiles | ||||||||||
| ≤ 0.82 mmol/l | 153 | 1.00 | 77 | 1.00 | 33 | 1.00 | 14 | 1.00 | 29 | 1.00 |
| 0.83–1.22 mmol/l | 158 | 0.69 (0.42–1.11) | 78 | 1.19 (0.53–2.66) | 33 | 0.50 (0.17–1.46) | 14 | 0.13 (0.03–0.64) | 33 | 0.96 (0.35–2.62) |
| ≥ 1.23 mmol/l | 153 | 1.24 (0.78–1.99) | 73 | 1.26 (0.57–2.78) | 33 | 1.01 (0.36–2.78) | 15 | 0.06 (0.01–0.55) | 32 | 2.99 (1.17–7.63) |
| p-trend | 0.351 | 0.838 | 0.179 | 0.001 | 0.011 | |||||
| Total-cholesterol | ||||||||||
| Continuous, mmol/l | 464 | 1.03 (0.90–1.19) | 228 | 1.06 (0.83–1.36) | 99 | 1.00 (0.66–1.51) | 43 | 1.05 (0.70–1.57) | 94 | 1.05 (0.77–1.44) |
| Tertiles | ||||||||||
| ≤ 5.14 mmol/l | 155 | 1.00 | 77 | 1.00 | 37 | 1.00 | 11 | 1.00 | 30 | 1.00 |
| 5.15–6.25 mmol/l | 156 | 1.33 (0.80–2.22) | 82 | 1.66 (0.70–3.95) | 27 | 0.85 (0.29–2.50) | 16 | 1.28 (0.18–7.93) | 31 | 1.01 (0.39–2.67) |
| ≥ 6.26 mmol/l | 153 | 1.46 (0.87–2.44) | 69 | 1.48 (0.61–3.60) | 35 | 1.20 (0.38–3.72) | 16 | 2.04 (0.34–12.3) | 33 | 1.41 (0.49–4.06) |
| p-trend | 0.354 | 0.512 | 0.830 | 0.533 | 0.731 | |||||
| HDL-cholesterol/total-cholesterol ratio | ||||||||||
| Continuous, | 464 | 0.89 (0.58–1.36) | 228 | 0.68 (0.02–25.0) | 99 | 0.23 (0.01–54.2) | 43 | 693 (0.06–747) | 94 | 0.02 (0.00–1.39) |
| Tertiles | ||||||||||
| ≤ 0.27 | 154 | 1.00 | 76 | 1.00 | 32 | 1.00 | 21 | 1.00 | 25 | 1.00 |
| 0.28–0.34 | 154 | 0.84 (0.65–1.29) | 67 | 0.81 (0.37–1.79) | 37 | 1.48 (0.57–3.87) | 14 | 1.53 (0.45–5.23) | 36 | 0.53 (0.24–1.19) |
| ≥ 0.35 | 156 | 0.82 (0.51–1.33) | 85 | 1.05 (0.43–2.00) | 30 | 0.96 (0.33–2.74) | 8 | 5.61 (0.62–21.0) | 33 | 0.33 (0.12–0.89) |
| p-trend | 0.385 | 0.819 | 0.986 | 0.176 | 0.026 | |||||
Multivariable Cox proportional hazard regression models
aNumber of deaths
Adjusted for age (continuous), Body mass index (continuous), and current smoking (categorical) at blood sampling, age at diagnosis (continuous), and disease stage (categorical)
Abbreviations: HDL high density lipoprotein, HR hazard ratio; n number of cases, t Total, TNBC triple negative breast cancer