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. 2018 Jun 15;15:185. doi: 10.1186/s12974-018-1219-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — M(−) BMDM show moderate to high expression of genes that are commonly associated with a pro-regenerative/M2 phenotype. Cluster analysis of log transformed gene expression data from BMDM that were stimulated in vitro with polarizing ligands IL4 or IFNγ+LPS. Three transgenic mouse strains and their background WT strains were compared. Clustering was performed separately by background strain. In both groups, M(−) BMDM expressed many genes that are classically considered pro-regenerative or M2 (a, cluster 2; b, cluster 3). a Ifngr1^−/− showed a distinct pattern of gene expression after IFNγ+LPS stimulation, but Il10rb^−/− showed no difference from WT. b Il4ra^−/− did not respond to IL4 stimulation and Il4ra^−/− M(IL4) clustered with WT M(−). n = 4–5/group