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. 2018 Jun 15;15:185. doi: 10.1186/s12974-018-1219-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Macrophage phenotype influences gene expression of neurotrophic and growth factors relevant to peripheral nerve repair. Pro-inflammatory macrophages have higher expression of pro-angiogenic growth factors: Vegfa is consistently upregulated by IFNγ+LPS stimulation, while Pdgfb is downregulated by IL4 stimulation. Insulin-like growth factors, Igf1 and Igf2 are upregulated by IL4. Plot of gene expression Log2(fold change) over the unstimulated M(−) condition for BMDM of 5 strains of mice exposed to IL4 or IFNγ+LPS stimulation. n = 4–5/group