Figure 1.

Approaches to predicting drug cardiotoxicity. The Research Topic includes: (1) studies of ion channel structure and function and drug interaction, ranging from atomistic models to kinetic models of whole-cell ion currents (Top); (2) mechanistic models of single cardiac myocyte electrophysiology, development of metrics for quantification of torsadogenic risk, and population-based approaches accounting for cell-to-cell variability (Middle); and (3) tissue/organ/organism level studies spanning tissue-level to whole heart and torso simulations, ex vivo recordings in animal preparations, and human clinical trials (Bottom).