Fig. 5.

DOX affects the serum concentrations of E2 and P4 following exogenous administration in ovariectomized SHRs. a, b Serum concentrations of E2 and P4 were measured in ovariectomized SHRs implanted with no pellet (sham) or a pellet containing a vehicle matrix (control), E2, P4, Tam, and a combination of E2 + P4 and E2 + Tam at day 5, which is before any DOX treatment (ANOVA, n = 6–8 per implant, *p  <0.05 according to Dunnett’s multiple comparison between implants). c, d E2 and P4 concentrations were measured at days 8 and 12 after DOX treatment in pellet-implanted SHRs (two-ANOVA, n = 3–4 per implant per treatment, *p  <0.05 according to Tukey’s multiple comparison between implants and treatment). The bars represent the mean ± SEM