Fig. 5.

Genes and pathways associated with species interaction and cross-feeding phenotypes. a The fraction of genes whose deletion is associated with each interaction type that are assigned to each pathway. The overall size of the pie indicates the number of genes associated with that interaction type. Pathways that are significantly enriched among this set of genes are highlight (bold font and asterisk). Only pathways that contain > 4% of the genes are listed (the rest are pooled into the ‘Other’ category) b Associations between providing or depending on specific metabolites and deletion or retention of specific genes. Orange (purple) bars indicate genes that are lost (retained) significantly more often in species that provide or depend on a specific metabolite compared to independent species. Genes are sorted by membership to pathways (see (c)), and only genes present in at least one pathway are shown. c Pathway membership of genes. Black bars indicate that a gene belongs to that pathway. Pathways are sorted by the number of genes assigned to them, and only pathways with five or more assigned genes are shown