Table 2.
S. aureus genetic characteristics in 98 endocarditis patients and their association with embolism.
| Univariate analysis | |||||
|---|---|---|---|---|---|
| Total population (n = 98) | Embolism (n = 54) | No embolism (n = 44) | OR (95% CI) | P-valuea | |
| GENETIC MARKERS WITH WALD TEST P-VALUE<0.10 | |||||
| mecA: alternate penicillin binding protein 2, defining MRSA | 11 | 1 (9.1) | 10 (90.9) | 0.06 (0.01–0.52) | 0.01 |
| tst1: toxic shock syndrome toxin 1 | 8 | 7 (87.5) | 1 (12.5) | 6.40 (0.76–54.2) | 0.09 |
| sed: staphylococcal enterotoxin D | 13 | 1 (7.7) | 12 (92.3) | 0.05 (0.01–0.41) | <0.01 |
| sej: staphylococcal enterotoxin J | 13 | 1 (7.7) | 12 (92.3) | 0.05 (0.01–0.41) | <0.01 |
| ser: staphylococcal enterotoxin R | 13 | 1 (7.7) | 12 (92.3) | 0.05 (0.01–0.41) | <0.01 |
| lukE: leukocidin E component | 44 | 20 (45.5) | 24 (54.5) | 0.42 (0.17–1.00) | 0.05 |
| GENETIC BACKGROUND | |||||
| agr (4 groups) | |||||
| I | 50 | 28 (56.0) | 22 (44.0) | 1.08 (0.49–2.39) | 0.86 |
| II | 33 | 14 (42.4) | 19 (57.6) | 0.46 (0.20–1.08) | 0.07 |
| III | 14 | 12 (85.7) | 2 (14.3) | 6.00 (1.26–28.46) | 0.02 |
| IV | 1 | 0 (0.0) | 1 (100.0) | – (–) | 0.99 |
| CLONAL COMPLEX | |||||
| CC15 | 11 | 6 (54.5) | 5 (45.5) | 0.98 (0.28–3.44) | 0.97 |
| CC30 | 11 | 10 (90.9) | 1 (9.1) | 9.77 (1.20–79.7) | 0.03 |
| CC398 | 5 | 3 (60.0) | 2 (40.0) | 1.24 (0.20–7.74) | 0.82 |
| CC45 | 15 | 7 (46.7) | 8 (53.3) | 0.67 (0.22–2.02) | 0.48 |
| CC5 | 19 | 7 (36.8) | 12 (63.2) | 0.40 (0.14–1.12) | 0.08 |
| CC8 | 13 | 6 (46.2) | 7 (53.8) | 0.66 (0.20–2.13) | 0.49 |
| Othersb | 24 | 15 (62.5) | 9 (37.5) | 1.50 (0.58–3.84) | 0.40 |
MRSA, methicillin-resistant Staphylococcus aureus.
a
P-value from Wald test, logistic regression.
b
CCs classified as others were CC1, CC10, CC12, CC121, CC20, CC25, CC7, CC8/ST7, CC88, CC9, CC97, ST188 and ST6.