Table 3.

Clinical and microbiological predictors of embolism in patients with S. aureus endocarditis in a regularized logistic regression model.

	Adjusted OR (95% CI)	P-value
CLINICAL PREDICTORS
Age ≥ 62.5 y (median)	0.01 (0.00–0.57)	0.024
Intravenous drug use	104.57 (1.70–6450.58)	0.027
Tricuspid endocarditis	12.04 (0.23–623.67)	0.217
Charlson comorbidity index	2.39 (0.06–102.00)	0.649
Diabetes mellitus	1.81 (0.04–76.02)	0.755
Septic shock (before surgery)	1.62 (0.04–72.48)	0.803
CRP at admission, mg/L	0.76 (0.02–32.95)	0.885
Initial size of the vegetation, mm	1.04 (0.03–39.80)	0.983
MICROBIOLOGICAL PREDICTORS
sedjr	0.01 (0.00–0.43)	0.018
mecA	0.06 (0.00–4.02)	0.193
tst1	3.71 (0.08–168.70)	0.501
lukE	2.77 (0.06–119.10)	0.595
Agr group
agr I (reference)	–	–
agr II	0.20 (0.00–8.65)	0.400
agr III	4.37 (0.09–209.30)	0.455
agr IV	0.08 (0.00–4.14)	0.208
Clonal complex
CC30	27.23 (0.66–1121.93)	0.082
CC5	0.61 (0.01–26.75)	0.795

Regularization parameter Lambda = 0.026, selected automatically based on 8 principal components (Cule and De Iorio, 2013).