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. 2018 May 21;115(23):E5289–E5297. doi: 10.1073/pnas.1805257115

Fig. 1.

Fig. 1.

Depletion of CRTC3 in BAT increases thermogenesis. (A) Body weight and fat mass of ad libitum-fed 10-wk-old WT control (CRTC3 fl/fl) and CRTC3 BAT knockout (BKO) mice on a normal chow diet (NCD). n = 3 and 5 per group. (B, Top) Effect of high-fat diet (HFD) on body weight (after 4 wk) and fat mass (after 12 wk) in BKO mice and control littermates. (B, Bottom) Circulating concentrations of leptin and norepinephrine in HFD-fed (after 4 wk) mice. n = 4 and 7 per group. (C) Indirect calorimetric analysis of BKO and control littermates, monitored for 48 h following cage adaptation. n = 4 per group. (D) Core body temperatures in NCD-fed control and CRTC3 BKO mice following cold exposure (4–5 °C) for times indicated. n = 5 per group. (E) Glucose tolerance test (GTT) (1.5 g/kg glucose) of high-carbohydrate diet (HCD) (16 wk)-fed mice. n = 6 and 8 per group. (Right) Area under curve for GTT. Data for A–E represent means ± SEM (*P < 0.05; **P < 0.01).