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. 2018 May 21;115(23):5998–6003. doi: 10.1073/pnas.1712955115

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Fig. 6. — Hemizygous loss of Tsc1 is not associated with an increase in niche number or cells per niche in early and late gestation. (A–C) OPT-based niche (A and B) and cell (C) counts derived from confocal images of Six2 antibody-stained kidneys from wild-type (1) and Six2^TGC+/tg (2) controls and Six2^TGC+/tg Tsc1^+/f-hemizygous (3) kidneys at PCD15.5 (A) and PCD19.5 (B). Cell numbers per niche (C) were counted at PCD15.5 (1a, 2a, and 3a) and PCD19.5 (1b, 2b, and 3b). (D) The Tsc1-mediated increase in nephron number requires Raptor. Shown are nephron counts in wild-type controls (1), Six2^TGC+/tg (4), Six2^TGC+/tg Rap^+/f (5), and Six2^TGC+/tg; Rap^+/f; Tsc1^+/f (6) kidneys. Glomeruli were counted from a single kidney removed from pups aged between P7 and P11. All litters were born at the same time as controls. *P < 0.05; *** P < 0.0001.