Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 10;29(2):111–127. doi: 10.1089/ars.2017.7097

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2018, Mary Ann Liebert, Inc.

PMC Copyright notice

FIG. 4. — MSC, regardless of the low expression of both heme oxygenases 1 or 2, show high resistance to hemin or hydrogen peroxide. LDH release in MSC Hmox1^+/+ or Hmox1^−/− treated with H₂O₂ (A) or hemin (B) in low or high glucose medium. Cell death in MSC Hmox1^+/+ or Hmox1^−/− treated with increasing concentrations of hemin for 6 h, assessed with 7-AAD staining and flow cytometry (C). Data are shown as mean ± SD. ***p < 0.001 two-way ANOVA with Bonferroni post-test, N = 3. Total antioxidant capacity of conditioned media from MSC Hmox1^+/+ or Hmox1^−/−, measured with TAC kit (N = 4) (D). (E) Expression of Hmox1, (F) Hmox2 in murine bone marrow PAC and MSCs isolated from Hmox1^+/+ or Hmox1^−/− mice, ****p < 0.0001 MSC versus PAC; two-way ANOVA with Bonferroni post-test, N = 3. 7-AAD, 7-aminoactinomycin D; ANOVA, analysis of variance; LDH, lactate dehydrogenase; PAC, pro-angiogenic cell; TAC, total antioxidant capacity.