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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Am J Psychiatry. 2012 Oct;169(10):1056–1064. doi: 10.1176/appi.ajp.2012.12020276

Table 2.

Sensitivity and Specificity of DSM-5 and DSM-IV

Clinical Diagnoses CPEA UMACC SSC Combined Samples
Autism
n = 778		 PDD or
Asperger
n = 78		 All PDD
Combined
n = 856		 Non-PDD
n = 163		 Autism
n =974		 PDD or
Asperger
n= 490		 All PDD
Combined
n= 1463		 Non-PDD
n= 527		 Autism
n= 1466		 PDD
n= 428		 Asperger
n= 236		 All PDD
Combined
n= 2130		 All PDD
Combined
n = 4453		 Non-PDD
n = 690
Sensitivity Specificity Sensitivity Specificity Sensitivity Sensitivity Specificity
EXTRACTED FROM ADI-R ONLY
DSM-5 ASD Criteria – One Symptom1 .94 .77 .93 .63 .95 .78 .89 .49 .93 .83 .94 .91 .91 .53
DSM-IV Autistic Disorder Criteria2 .89 .69 .87 .72 .95 .78 .89 .48 .95 .88 .93 .93 .91 .53
DSM-IV Asperger Criteria3 .97 .86 .96 .51 .99 .90 .96 .30 .99 .92 .99 .97 .97 .34
DSM-IV PDD-NOS Criteria4 .99 .92 .98 36 .99 .93 .97 .20 .99 .96 .98 .98 .98 .24
EXTRACTED FROM ADI-R AND ADOS
DSM-5 ASD Criteria – One Symptom5 .99 .94 .99 .50 .99 .93 .97 .28 .99 .99 1.0 .99 .99 .33
DSM-5 ASD Criteria – Two Symptoms6 .85 .51 .82 .78 .86 .70 .80 .62 .97 .87 .95 .95 .88 .66
DSM-5 ASD Criteria – Two Symptoms, One Less Sub-Domain7 .99 .92 .98 .58 .99 .94 .97 .37 .99 .99 .99 .99 .99 .42
DSM-IV Autistic Disorder Criteria8 .98 .84 .96 .46 .99 .90 .96 .29 .99 .98 .97 .99 .97 .33
DSM-IV Asperger Criteria9 .99 .94 .99 .34 .99 .98 .99 .15 .99 .99 1.0 .99 .99 .19
DSM-IV PDD-NOS Criteria10 1.0 .99 .99 .18 1.0 .99 .99 .07 1.0 1.0 1.0 1.0 .99 .10
EXTRACTED FROM ADI-R AND ADOS: SYMPTOMS REQUIRED FROM BOTH
DSM-5 ASD Criteria11 .93 .69 .91 .69 .96 .72 .88 .62 .93 .80 .92 .90 .90 .63
DSM-IV Autistic Disorder Criteria12 .93 .62 .90 .94 .96 .76 .89 .57 .96 .89 .92 .94 .92 .61
DSM-IV Asperger Criteria13 .97 .77 .95 .60 .99 .85 .94 .47 .99 .94 .97 .98 .96 .50
DSM-IV PDD-NOS Criteria14 .97 .82 .96 .59 .99 .86 .95 .44 .99 .95 .97 .98 .96 .47
1

At least 1 ADI-R symptom from each A sub-domain and at least 1 ADI-R symptom from 2 or more B sub-domains

2

At least 1 ADI-R symptom from 2 or more A sub-domains, at least 1 ADI-R symptom from 1 or more B sub-domains, at least 1 ADI-R symptom from 1 or more C sub-domains, and having at least 1 ADI-R symptom in 6 or more sub-domains across A, B, and C

3

At least 1 ADI-R symptom from 2 or more A sub-domains and at least 1 ADI-R symptom from 1 or more C sub-domains

4

At least 1 ADI-R symptom from 2 or more A sub-domains and at least 1 ADI- R symptom from 1 or more B OR C sub-domains

5

At least 1 ADI-R or ADOS symptom from each A sub-domain and at least 1 ADI-R or ADOS symptom from 2 or more B sub-domains

6

At least 2 ADI-R or ADOS symptoms from each A sub-domain and at least 2 ADI-R or ADOS symptoms from 2 or more B sub-domains

7

At least 2 ADI-R or ADOS symptoms from each A sub-domain and at least 2 ADI-R or ADOS symptoms from 1 or more B sub-domains OR At least 2 ADI-R or ADOS symptoms from 2 or more A sub-domains and at least 2 ADI-R or ADOS symptoms from 2 or more B sub-domains (see Frazier et al., 2011)

8

At least 1 ADI-R or ADOS symptom from 2 or more A sub-domains, at least 1 ADI-R or ADOS symptom from 1 or more B sub-domains, at least 1 ADI-R or ADOS symptom from 1 or more C sub-domains, and having at least 1 ADI-R symptom in 6 or more sub-domains across A, B, and C

9

At least 1 ADI-R or ADOS symptom from 2 or more A sub-domains and at least 1 ADI-R or ADOS symptom from 1 or more C sub-domains

10

At least 1 ADI-R or ADOS symptom from 2 or more A sub-domains and at least 1 ADI- R or ADOS symptom from 1 or more B OR C sub-domains

11

At least 1 symptom (from ADI-R AND ADOS) from A1 and A2, at least 1 symptom (from either ADI-R OR ADOS) from A3, and at least 1 symptom (from either ADI-R OR ADOS) from 2 or more B sub-domains

12

At least 1 symptom (from ADI-R AND ADOS) from 2 or more A sub-domains, at least 1 symptom (from ADI-R AND ADOS) from 1 or more B sub-domains, at least 1 symptom (from either ADI-R OR ADOS) from 1 or more C sub-domains, and having at least 1 ADI-R or ADOS symptom in 6 or more sub-domains across A, B, and C

13

At least 1 symptom (from ADI-R AND ADOS) from 2 or more A sub-domains and at least 1 symptom (from either ADI-R OR ADOS) from 1 or more C sub-domains

14

At least 1 symptom (from ADI-R AND ADOS) from 2 or more A sub-domains and at least 1 symptom (from ADI-R AND ADOS) from 1 or more B sub-domains; OR at least 1 symptom (from ADI-R AND ADOS) from 2 or more A sub-domains and at least 1 symptom (from either ADI-R OR ADOS) from 1 or more C sub-domains