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. 2018 May 7;115(21):E4890–E4899. doi: 10.1073/pnas.1717106115

Fig. 5.

Fig. 5.

Presynaptic D1-type and D2-type receptors modulate PrL–NAc transmission in an opposite manner. (A) Paired stimuli with a 50-ms interval delivered to the PrL eEPSCs recorded from identified D2-MSNs. Application of the D1-type receptor partial agonist SKF38393 increased the amplitude of the eEPSCs while decreasing the PPR. (Left) A typical example. (Right) The pooled time course of the effect of SKF38393 on the eEPSC amplitude. (B) Summary of the population changes in amplitude and PPR. (C and D) The full D1-type receptor agonist SKF81297 exerted an effect similar to that of SKF38393 on the eEPSCs. (E and F) In contrast, superfusion of the D2-type receptor agonist quinpirole decreased the amplitude of eEPSCs with a concomitant increase in the PPR. *P < 0.05; **P < 0.01, paired t test. Data are presented as mean ± SEM.