Fig. 3.

Placental morphology in HMGA2 concepti at D78 of gestation. (A) HMGA2^−/+ placentas were healthy and well-vascularized, while HMGA2^−/− placentas showed lack of absorptive structures (areolae; arrowheads compared with arrows) and vascularization. (B) Histological analysis of placenta and endometrium from HMGA2^+/+, HMGA2^−/+, and HMGA2^−/− fetuses. Villi were severely degenerated in HMGA2^−/− placenta compared with other genotypes. Furthermore, poor contact of villi between uterine endometrium (Endo) and chorionic membrane (Chorio) was detected for HMGA2^−/− (arrow), suggesting the connection between uterus and placenta was deficient. (Scale bars: 100 μm.)