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. 2018 May 9;115(21):E4767–E4776. doi: 10.1073/pnas.1800541115

Fig. 5.

Fig. 5.

Application of IonStar in a large-scale quantitative investigation to explore the mechanism of TBI and pharmaceutical recovery (PBZ or METH). (A) Overview of study design. The cortex and hippocampus from 50 LFP rats with varied TBI severities and pharmacological treatments were included in the study (n = 100 in total). (B) Intensity distribution of the 7,190 proteins quantified without missing data. (C) Significantly changed proteins in the two brain regions. (D) PC analysis of significantly changed proteins. The untreated severe TBI groups are highlighted with shading. var., variation. (E) Abundance heat map of the 7,190 proteins quantified from the 100 brain samples.