Table 1.
Current density (pA/pF) |
Steady-state activation (SSA) |
Steady-state inactivation (SSI) |
||||||
---|---|---|---|---|---|---|---|---|
n | n | V1/2 (mV) | k | n | V1/2 (mV) | k | ||
Nav1.5 alone | 10 | −57.94 ± 19.34 | 13 | −22.70 ± 0.77 | 5.43 ± 0.17 | 12 | −68.06 ± 0.65 | 4.90 ± 0.19 |
Nav1.5 + β1 WT | 19 | −67.11 ± 10.04 | 12 | −23.90 ± 1.37 | 5.64 ± 0.19 | 14 | −68.94 ± 0.59 | 4.78 ± 0.11 |
Nav1.5 + β1B WT | 17 | −106.21 ± 11.71∗ | 10 | −23.83 ± 1.29 | 5.08 ± 0.17 | 13 | −65.50 ± 0.54∗ | 4.59 ± 0.14 |
Nav1.5 + β1B R225C | 23 | −111.41 ± 9.04∗ | 5 | −24.19 ± 0.69 | 5.32 ± 0.13 | 20 | −68.52 ± 0.52 | 4.77 ± 0.15 |
k = slope; n = number of recordings; V1/2 = voltage of half-maximal activation/inactivation.
P < .05 vs Nav1.5 alone, compared by paired 2-tailed Student t test.