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. 2018 Jun 1;9(42):26711–26723. doi: 10.18632/oncotarget.25475

Figure 5. Overview of the current study.

Figure 5

Integrated analysis of genome-wide methylation and gene- expression of leukemia cells obtained at diagnosis from patients enrolled in multicenter AML02 study identified 50 genes of significant prognostic value. DNMT3B is one of the top genes identified. Methylation of DNMT3B is potential regulator of own expression, and DNMT3B expression regulated genome-wide methylation burden, both of which are predictors of clinical outcome (AML02 study and validation in AAML0531). DNMT3B is correlated with expression and methylation levels of key candidate genes involved in various cellular pathways, which in turn are potential contributors to AML outcome. Also are shown genes of significance in AML as well as HOX family of genes with significant expression correlation with expression levels of DNMT3B.