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. 2018 Jun 1;9(42):26800–26816. doi: 10.18632/oncotarget.25508

Figure 4.

Figure 4

(A) Changes in extracellular acidification of HeLa cells after the treatment with VR16-09, VD11-4-2 or VD12-09 for 72 h under normoxia (21% O2; white bars) or hypoxia (0.2% O2; grey bars). (B–C) Effect of VR16-09 (B) and VD11-4-2 (C) on the hypoxia-induced extracellular acidification of H460, MDA-MB-231, A549, and AsPC-1 after the exposure for 72 h. Average ± SD of at least 3 independent experiments is shown. Asterisks indicate significant difference between medium pH of cells exposed to DMSO and cells treated with various doses of inhibitor under hypoxic conditions (*p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001).