Fig. 5. (a) MCF-7 cells were incubated for 24 h with IC50 concentrations of tested complexes. The HDAC activity was determined in cells (light blue bars) or in nuclear extracts (orange bars), *P < 0.05, **P < 0.01. (b) MCF-7 cells were incubated for 24 h with IC50 concentrations of either cisplatin or oxaliplatin and HDAC activity was determined. (c) MCF-7 cells were incubated for 24 h with increasing concentrations of tested complexes. HDAC IC50 values were calculated by 4 PL model (P < 0.05).
