Table 2. log P (octanol/water) values obtained by shake flask method a .
Compound | Formula | log P |
Cisplatin26 | –2.25 ± 0.04 | |
I | ctc-[Pt(NH3)2(VPA)2Cl2]26 | 0.25 ± 0.03 |
II | ctc-[Pt(NH3)2(Ac)(VPA)Cl2]26 | 0.17 ± 0.02 |
III | [Pt(DACH)(VPA)2(ox)]25 | 0.37 ± 0.08 |
IV | [Pt(DACH)(VPA)(OH)(ox)]25 | 0.10 ± 0.05 |
VI | ctc-[Pt(NH3)2(PhB)2Cl2] | –0.73 ± 0.05 |
VIII | [Pt(DACH)(PhB)2(ox)] | 0.25 ± 0.02 |
aResults are expressed as the mean ± SD from three independent experiments.