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. 2018 May 16;37(12):e99325. doi: 10.15252/embj.201899325

Figure 8. A model for the function of GTSF‐1.

Figure 8

  • GTSF‐1 forms a pre‐ERI complex together with RRF‐3 and ERI‐5. GTSF‐1 and ERI‐5 are both required to incorporate RRF‐3 into ERIC. Upon deposition of RRF‐3 in ERIC, GTSF‐1 may dissociate. It is unclear how stable is the association between GTSF‐1 and the mature complex. Also, this process of ERIC assembly seems to be developmentally regulated. See Discussion for details.