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. 2018 May 22;37(12):e99543. doi: 10.15252/embj.201899543

Figure 2. FAM35A is an OB‐fold protein with an N‐terminal disordered region.

Figure 2

  1. Domain schematic of human FAM35A derived from sequence prediction modeling. An N‐terminal disordered region includes post‐translational modification sites. Locations of the three OB‐fold domains A, B, and C are shown, with a Zn‐ribbon containing conserved Cys residues. One exon is absent in isoform 2 compared to isoform 1, deleting 69 aa from OB domain B.
  2. Multi‐species alignment of a segment of FAM35A protein in the predicted Zn‐ribbon. The four Zn‐coordinating Cys residues (CxxC, CxxC), homologous to those in human RPA1, are evolutionarily conserved.