Figure 8.

Effects of CBD on anxiety‐like behaviour in mice injected i.p. with vehicle (ethanol : cremophor : saline; 1:1:18; every 12 h) for 7 days. CBD (5, 10 and 20 mg·kg⁻¹, i.p.) or its vehicle (ethanol : cremophor : saline; 1:1:18) was administered approximately 12 h after the last vehicle administration. Mice received the CBD dose, and 90 min later, they were exposed to the light–dark box paradigm for 5 min. (A) The evaluation of the time in the light box and (B) the evaluation of the number of transitions. Columns represent the means and vertical lines ±SEM of time (s) in the light side and number of transitions. ^*Values from vehicle + CBD‐treated mice that are significantly different (P < 0.05) from the control group (vehicle + vehicle) (one‐way ANOVA followed by Student–Newman–Keul's test).