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Estimated plasma concentrations of histamine, PAF and PGD2 in anaphylaxis. The stimulation of antigen and its specific IgE initially activates mast cells and releases a large amount of histamine. A few minutes later, activated mast cells de novo synthesize and secrete PAF and PGD2. Following mast cell activation, the antigen and its specific IgG stimulate basophils and/or neutrophils to synthesize PAF de novo and release it in greater concentrations than that of mast cells.
