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. 2018 May 22;37(12):e98694. doi: 10.15252/embj.201798694

Figure 6. Loss of LRRK2 enhances innate immunity to Mtb in vivo .

Figure 6

  1. WT and LRRK2 KO mice were infected with a low dose of Mycobacterium tuberculosis strain H37Rv or N145. Growth of M. tuberculosis H37Rv or N145 in lungs was measured by CFU.
  2. Same as in panel (A) in spleens.
  3. Haematoxylin‐ and Eosin‐stained lung sections of one representative animal per genotype and Mtb strain on day 56 after infection.
  4. Quantification of the number of lesions and lesion area in infected lungs (n = 5).
  5. mRNA levels of cytokines were determined from whole lung homogenates 56 days post‐infection (n = 5).
Data information: All data represent mean ± SEM. Groups were compared using an unpaired t‐test, and all P‐values are corrected for multiple comparisons using the Holm‐Sidak method. *P < 0.05, **P < 0.01, ns = not significant. Each dot represents an individual animal.