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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Psychoneuroendocrinology. 2018 May 21;94:143–151. doi: 10.1016/j.psyneuen.2018.05.012

Figure 2.

Figure 2

Genetic knockout of IL-6 selectively improves retention of fear memory extinction. a Study design. b Freezing during CS exposures terminating with a footshock during fear conditioning in wild-type (WT) and IL-6−/− mice. c Conditioned freezing in response to extinction training with 12 CS four days after conditioning. d Testing for retention of fear memory extinction with 4 CS one day after extinction training. e Total average conditioned freezing in response to four CS during extinction training (Day 5) and testing (Day 6). (n=8/group) *P<0.05, ^P<0.01, #P<0.001. “Pre” = 2-min period before CS presentations begin.