Table 1.
Baseline characteristics.
| Baseline Characteristics | Total (n=117), n (%) |
|---|---|
| Demographics | |
| Age, years | 60 (52-66) |
| Men | 83 (71%) |
| Time from transplant to PET imaging, years | 6.4 (3.5-10.0) |
| Follow-up, years | 1.4 (0.9-2.4) |
| Transplant Indication | |
| Ischemic cardiomyopathy | 77 (66%) |
| Nonischemic cardiomyopathy | 40 (34%) |
| Immunosuppression | |
| Tacrolimus | 102 (87%) |
| Sirolimus or Everolimus | 24 (21%) |
| Cyclosporine | 12 (10%) |
| Mycophenolate mofetil | 63 (54%) |
| Azathioprine | 8 (7%) |
| Prednisone | 77 (66%) |
| Other Medications | |
| Aspirin | 103 (88%) |
| Statin | 102 (87%) |
| Vitamin C | 88 (75%) |
| Vitamin E | 82 (70%) |
| Comorbidities | |
| Diabetes mellitus | 47 (40%) |
| Hypertension | 101 (86%) |
| Chronic kidney disease (GFR < 60 mL/min per 1.73 m2) | 75 (64%) |
| Body mass index, kg/m2 | 30.0 (26.1-34.6) |
| Previously documented cardiac allograft vasculopathy, n | 21 (18%) |
| Previous revascularization | 4 (3%) |
| Prior ≥ 2R cellular rejection or antibody-mediated rejection | 42 (36%) |
| PET Imaging Data | |
| Summed stress score | 1 (0-2) |
| Summed rest score | 1 (0-2) |
| Summed difference score | 0 (0-1) |
| Rest ejection fraction, % | 61 (56-65) |
| LV volume ratio at stress/rest | 1.02 (0.96-1.06) |
| Rest myocardial blood flow, mL/g per minute | 1.59 (1.35-1.93) |
| Stress myocardial blood flow, mL/g per minute | 3.60 (3.11-4.16) |
| Myocardial flow reserve | 2.31 (1.84-2.72) |
| Myocardial flow reserve < 2.0 | 33 (28%) |
Continuous variables reported as median (25% and 75% percentiles). GFR = glomerular filtration rate.