Table 4.
Baseline characteristics for patients with and without CAV by ISHLT criteria.
| Variable | CAV (n=22) | No CAV (n = 20) | P Value |
|---|---|---|---|
| Age, years | 58.5 (53.5-64.5) | 61.0 (56.0-66.3) | 0.503 |
| Men | 12 (54%) | 15 (75%) | 0.289 |
| Time OHT to PET, yrs | 8.69 (4.34-14.4) | 3.84 (2.22-5.44) | 0.001 |
| Immunosuppression | |||
| Tacrolimus | 17 (77%) | 20 (100%) | 0.073 |
| Sirolimus or Everolimus | 11 (50%) | 2 (10%) | 0.014 |
| Cyclosporine | 3 (14%) | 0 | 0.265 |
| Mycophenolate mofetil | 8 (36%) | 12 (60%) | 0.222 |
| Azathioprine | 2 (9%) | 0 | 0.512 |
| Prednisone | 14 (64%) | 12 (60%) | 0.999 |
| Comorbidities | |||
| Diabetes mellitus | 9 (41%) | 11 (55%) | 0.546 |
| Hypertension | 18 (82%) | 16 (80%) | 0.999 |
| CKD (GFR < 60 mL/min) | 18 (82%) | 10 (50%) | 0.512 |
| Body mass index, kg/m2 | 31.2 (26.5-35.4) | 28.1 (24.5-32.0) | 0.064 |
| Hx ≥ 2R rejection or AMR | 8 (36%) | 7 (35%) | 0.999 |
| PET Imaging Data | |||
| Summed stress score | 4.5 (2.0-7.5) | 1.0 (0-3.25) | 0.220 |
| Summed rest score | 2.0 (1.0-3.0) | 1.0 (0-2.0) | 0.272 |
| Summed difference score | 1.5 (0-4.8) | 0 (0-0.2) | 0.034 |
| Rest ejection fraction, % | 58 (55-64) | 63 (59-68) | 0.398 |
| Rest MBF, mL/g/min | 1.55 (1.37-1.93) | 1.66 (1.31-2.08) | 0.537 |
| Stress MBF mL/g/min | 2.96 (2.42-3.48) | 3.90 (3.31-4.90) | < 0.001 |
| Myocardial flow reserve | 1.75 (1.46-2.52) | 2.46 (2.14-2.84) | 0.017 |
| MFR < 2.0 | 12 (54%) | 3 (15%) | 0.019 |
Continuous variables reported as median (25% and 75% percentiles).