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. 2017 Dec 28;316:80–97. doi: 10.1016/j.jneuroim.2017.12.018

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Fig. 3 — Infiltration of macrophages and activation of microglia/macrophages in the CNS occurs during MV-infection in an IFNγ-independent manner.

Whole brain homogenates from CD46+ (A) and CD46+/IFNγ-KO (B) neonates were analyzed for microglia (A; CD45^intermediate) and macrophages (B; CD45^high) by flow cytometry. The horizontal line represents the mean number of cells for each condition. Results from 4 to 5 different litters were collected, and statistical analysis was applied by two-way ANOVA (#p < 0.001, *p < 0.05) with Bonferroni post hoc test. Whole brains from MV-infected and uninfected control CD46+ neonates (C) and CD46+/IFNγ-KO neonates (D) were collected at 7 dpi. Sagittal sections from the neocortex were immunostained for measles (Hemagglutinin and Matrix protein; red), microglia/macrophages (Iba1; green) and Hoechst 33,342 stain (blue) as a nuclear marker. Slides from 4 to 5 mice per condition were examined, and representative sections with MV + cells are shown. Scale bar = 200 μm. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)