TABLE 3.
Model 2: Unadjusted and Adjusted Association Between Patient Characteristics and Medications at Enrollment with KCCQ-os (N = 3,494)
| Unadjusted Effect (95% CI) |
p Value | Adjusted Effect (95% CI) |
p Value | |
|---|---|---|---|---|
| Age, 10-yr increments | ||||
| ≤70 yrs | 1.2 (0.5 to 1.8) | <0.001 | 1.6 (0.6 to 2.6) | 0.002 |
| ≥70 yrs | −0.2 (−1.7 to 1.3) | 0.765 | −5.5 (−7.5 to −3.4) | <0.001 |
|
| ||||
| Female (ref: male) | −4.8 (−6.5 to −3.1) | <0.001 | −2.2 (−3.8 to −0.6) | 0.007 |
|
| ||||
| Race/ethnicity (ref: white) | ||||
| Black | −4.5 (−6.7 to −2.2) | <0.001 | −0.4 (−2.5 to 1.8) | 0.736 |
| Other | 0.1 (−2.8 to 3.1) | 0.930 | 3.1 (0.3 to 5.9) | 0.031 |
| Hispanic (ref: non-Hispanic) | −3.4 (−6.1 to −0.6) | 0.016 | −4.0 (−6.6 to −1.3) | 0.003 |
|
| ||||
| BMI to per 7.2 U | −3.3 (−4.0 to −2.5) | <0.001 | −2.5 (−3.3 to −1.8) | <0.001 |
|
| ||||
| Total household income (ref: <$25,000) | ||||
| $25,000–$49,999 | 4.8 (2.6 to 7.1) | <0.001 | 0.7 (−1.4 to 2.8) | 0.505 |
| $50,000–$74,999 | 10.1 (7.5 to 12.7) | <0.001 | 3.2 (0.7 to 5.7) | 0.013 |
| $75,000–$99,999 | 10.8 (7.4 to 14.2) | <0.001 | 3.8 (0.6 to 7.0) | 0.019 |
| $100,000–$149,999 | 14.2 (10.6 to 17.8) | <0.001 | 4.7 (1.3 to 8.1) | 0.007 |
| $150,000 or more | 15.3 (10.4 to 20.1) | <0.001 | 4.7 (0.1 to 9.2) | 0.045 |
| Prefer not to answer | −0.9 (−2.6 to 0.7) | 0.267 | −1.8 (−3.3 to −0.2) | 0.029 |
|
| ||||
| Employment status (ref: working full-time) | ||||
| Working part-time | −2.8 (−6.1 to 0.6) | 0.107 | −1.3 (−4.5 to 1.9) | 0.417 |
| Disability for medical reasons | −20.4 (−22.8 to −17.9) | <0.001 | −14.3 (−16.8 to −11.8) | <0.001 |
| Not employed for other reasons | −7.4 (−9.6 to −5.2) | <0.001 | −5.0 (−7.4 to −2.5) | <0.001 |
|
| ||||
| COPD | −10.4 (−12.1 to −8.7) | <0.001 | −6.2 (−7.7 to −4.6) | <0.001 |
|
| ||||
| Chronic kidney disease | −6.4 (−8.3 to −4.4) | <0.001 | −2.6 (−4.4 to −0.8) | 0.005 |
|
| ||||
| Depression | −10.5 (−12.3 to −8.7) | <0.001 | −7.3 (−9.0 to −5.7) | <0.001 |
|
| ||||
| Atrial fibrillation | −2.0 (−3.6 to −0.4) | 0.015 | −2.0 (−3.5 to −0.5) | 0.011 |
|
| ||||
| Coronary artery disease | −0.9 (−2.6 to 0.7) | 0.267 | −1.8 (−3.3 to −0.2) | 0.029 |
|
| ||||
| Prior HF hospitalization in past year (ref: 0) | ||||
| 1 | −5.2 (−7.1 to −3.4) | <0.001 | −2.8 (−4.5 to −1.2) | 0.001 |
| ≥2 | −13.2 (−15.6 to −10.7) | <0.001 | −6.6 (−8.9 to −4.3) | <0.001 |
|
| ||||
| Pulse, per 12.5 beats/min | −4.0 (−4.8 to −3.2) | <0.001 | −2.4 (−3.1 to −1.7) | <0.001 |
|
| ||||
| LVEF, per 8% | 2.2 (1.5 to 3.0) | <0.001 | 1.1 (0.4 to 1.9) | 0.003 |
|
| ||||
| ARNI | 1.2 (−1.3 to 3.6) | 0.3474 | 3.9 (1.5 to 6.4) | 0.002 |
|
| ||||
| ACEi/ARB | 3.6 (2.0 to 5.2) | <0.001 | 3.6 (2.0 to 5.3) | <0.001 |
|
| ||||
| Loop diuretic agent | −8.2 (−9.8 to −6.6) | <0.001 | −4.4 (−6.0 to −2.9) | <0.001 |
|
| ||||
| Ivabradine | −10.2 (−17.2 to −3.2) | 0.004 | −6.9 (−13.2 to −0.6) | 0.033 |
|
| ||||
| Inotrope | −25.8 (−37.9 to −13.6) | <0.001 | −17.0 (−27.9 to −6.1) | 0.002 |
Abbreviations as in Table 1.