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. Author manuscript; available in PMC: 2019 May 10.
Published in final edited form as: Eur J Med Chem. 2018 Apr 11;151:815–823. doi: 10.1016/j.ejmech.2018.04.021

Fig. 4.

Fig. 4

Best docking pose for hMC1R selective ligand: Ac-His-D-Phe(4-CF3)-Nle-Trp-NH2 into hMC1R. (Docking Score −11). The hMC1R-MCL interactions distance cut off 3 Å. Up Left: the selective molecule is highlight as tubing structure. The D-Phe(4-CF3) and Trp of the tetra peptide form π-π stacking interactions with the hMC1R transmembrane domains. Up Right: 3D view of selective molecule docking into hMC1R. Down: 2D structure of hMC1R-MCL interactions.