Table 1.
Genes differentially expressed in the kidney cortex of Hb AS and Hb SS mice using an additive model.
| Gene | β value | FDR | Mechanistic Pathway |
|---|---|---|---|
| AKR1C18 | −1.12 | 0.007 | Oxidoreductase activity; catalyzes reduction of prostaglandins |
| HbA-A2 | 0.99 | 0.009 | Alpha chain of hemoglobin |
| HMOX1 | 0.93 | 0.0099 | Essential enzyme for heme degradation |
| SLC4A1 | 0.87 | 0.005 | Chloride/HCO3 exchange involved in kidney acid secretion |
| FASN | 0.87 | 0.007 | Regulates cholesterol biosynthesis |
| AQP6 | 0.80 | 0.006 | Kidney-specific water channel functioning in glomerular filtration |
| RSAD2 | 0.76 | 0.004 | IFNα/β signaling involved in CD4+cell activation and differentiation |
| C3 | 0.76 | 0.0099 | Central role in complement activation |
| SLC25A37 | 0.75 | 0.004 | Mitochondrial iron importer |
| UBE2O | 0.72 | 0.005 | Immune/antigen processing for ubiquination and proteosome degradation |