Table 2.
Angiogenic and anti-angiogenic factors in corneal neovascularization165 (Pending Approval)
| Angiogenic molecules | Anti-angiogenic molecules |
|---|---|
| Vascular endothelial growth factors (VEGFs) | Pigment epithelium-derived factor (PEDF) |
| Fibroblast growth factor (FGF) | Endostatin |
| Phosphatidylinositol-glycan biosynthesis class F or Placental growth factor (PlGF) | Angiostatin |
| Transforming growth factor alpha (TGF-α), TGF-β | Prolactin (PRL) |
| Insulin-like growth factor (IGF) | Tissue inhibitor metalloproteinases (TIMPs) |
| Platelet-derived growth factor (PDGF) | Thrombospondin (TSP)-1, TSP-2 |
| Matrix metalloproteinases (MMPs) | Interleukin (IL)-4, -12, -13, -18 |
| Hepatocyte growth factor (HGF)/Scatter factor (SF) | Arresten |
| Tumor necrosis factor alpha(TNF-α) | Canstatin |
| Connective tissue growth factor(CTGF) | Tumstatin |
| IL-1, -8 | TNF-α |
| Monocyte chemoattractant protein (MCP)-1 | MMPs |
| Leptin | Interferon gamma (IFN-γ) |
| Integrins (αV β3) | |
| Angiogenin | |
| Thromboxane (TXA)-2, Cyclooxygenase (COX)-2 | |
| Nitric Oxide (NO) | |
| Platelet activating factor (PAF) |