Skip to main content
. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Cytokine. 2018 Feb 15;109:2–10. doi: 10.1016/j.cyto.2017.12.022

Figure 1.

Figure 1

CXCL12 and CXCR4 structure and molecular interactions. A) Structure. Crystal structure of the monomer forms are shown for CXCL12 and CXCR4 complexed with the small molecular weight antagonist IT1t [41]. B) Molecular interactions. Some demonstrated binding interactions are shown for CXCL12, CXCR4, ACKR3 and several non-chemokine ligands for CXCR4 and ACKR3. See text for details and references. Abbreviations: MIF, macrophage migration inhibitory factor; AM, adrenomedullin; HMGB1, high mobility group-box 1.