Table 2.
Hematological and biochemical parameters in arterial blood from rats in the Control, CCl4-1xWk and CCl4-2xWk groups.
| Control (n = 11) | CCl4-1xWk (n = 10)# | CCl4-2xWk (n = 10)# | |
|---|---|---|---|
| Blood cell count | |||
| Red blood cells (x10 6 /μl) | 7.7 [7.2, 8.0] | 7.6 [7.5, 7.8] | 6.9 [6.4, 7.5] |
| Hemoglobin (g/dl) | 14.0 [13.6, 14.6] | 13.6 [13.3, 14.2] | 13.2 [12.5, 13.6]* |
| Hematocrit (%) | 40.2 [38.7, 41.7] | 39.8 [38.7, 40.8] | 38.8 [38.1, 40.6] |
| MCV (fl) | 54.3 [51.2, 54.9] | 52.3 [50.6, 54.4] | 56.7 [54.1, 61.0]θ |
| White blood cells (x10 3 /μl) | 1.5 [0.9, 3.7] | 1.1 [0.9, 2.2] | 7.2 [2.6, 15.8]*,θ |
| Platelets (x10 3 /μl) | 886 [859, 1011] | 866 [798, 955] | 525 [363, 706]**,θ |
| Coagulation | |||
| Prothrombin time (s) | 11.5 [10.0, 12.6] | 11.7 [11.2, 11.9] | 15.1 [13.3, 17.0]**,θθ |
| INR | 1.05 [0.91, 1.16] | 1.07 [1.05, 1.10] | 1.39 [1.23, 1.56]**,θθ |
| Fibrinogen (mg/dl) | 236 [194, 247] | 234 [212, 253] | 144 [97, 209]*,θθ |
| Blood biochemistry | |||
| Glucose (mg/dl) | 197 [166, 259] | 163 [160, 201] | 122 [101, 168]** |
| ALT (U/l) | 27 [25, 41] | 41 [28, 61] | 76 [54, 89] ****, θθ |
| AST (U/l) | 54 [47, 63] | 67 [46, 95] | 210 [170, 291]***,θθ |
| Total Bilirubin (mg/dl) | 0.10 [0.03, 0.10] | 0.10 [0.10, 0.10] | 0.45 [0.18, 0.90]**,θ |
| AP (U/l) | 66 [60, 75] | 125 [101, 147]** | 236 [127, 297]** |
| Albumin (g/dl) | 3.5 [3.2, 3.7] | 3.2 [3.2, 3.5] | 2.6 [2.1, 2.8]****,θθθθ |
| Total Proteins (g/dl) | 5.3 [5.2, 5.5] | 5.3 [5.0, 5.5] | 4.5 [4.2, 4.6]**,θθ |
| LDH (U/l) | 138 [110, 214] | 155 [92, 210] | 207 [198, 390]θ |
| Creatinine (mg/dl) | 0.34 [0.26, 0.36] | 0.28 [0.24, 0.34] | 0.20 [0.20, 0.24]* |
| Urea (mg/dl) | 28 [22, 32] | 27 [22, 32] | 20 [18, 25] |
| Sodium (mmol/l) | 137 [136, 140] | 139 [138, 142] | 139 [139, 142] |
| Potasium (mmol/l) | 4.9 [4.6, 5.8] | 5.3 [5.0, 5.5] | 5.6 [5.1, 6.2] |
| Arterial blood gases | |||
| pH | 7.39 [7.33, 7.47] | 7.44 [7.42, 7.48] | 7.38 [7.33, 7,43] |
| pCO 2 (mmHg) | 46 [40, 51] | 40 [36, 42] | 51 [46, 57]θθ |
| pO 2 (mmHg) | 441 [341, 478] | 455 [439, 478] | 409 [336, 435] |
| HCO 3 (mmol/l) | 28.2 [27.0, 28.6] | 27.3 [26.9, 27.8] | 29.8 [27.8, 30.2]θ |
| Lactate (mmol/l) | 1.0 [0.6, 1.2] | 1.0 [0.6, 1.1] | 0.9 [0.7, 1.0] |
Values are Median [interquartile range]. Abbreviations: ALT, alanine transaminase; AP, alkaline phosphatase; AST, aspartate transaminase; HCO3, bicarbonate; INR, international normalized ratio; LDH, lactate dehydrogenase; MCV, mean corpuscular volume; pCO2, partial pressure of carbon dioxide; pO2, partial pressure of oxygen.
#1 rat in the CCl4-1xWk group and 2 in the CCl4-2xWk group had no laboratory data.
*p < 0.05 vs. Control, **p < 0.01 vs. Control, ***p < 0.001 vs. Control, ****p < 0.0001 vs. Control, θp < 0.05 vs. CCl4-1xWk, θθp < 0.01 vs. CCl4-1xWk, θθθθp < 0.0001 vs. CCl4-1xWk.