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. 2018 Jun 15;4:18. doi: 10.1038/s41531-018-0054-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — SNCA genomic triplication neuropathology. a Gross pathology of midbrain and pons with loss of neuromelanin pigment in both; b alpha-synuclein immunohistochemistry of locus ceruleus with Lewy bodies and bizarre neuronal inclusions; c Numerous Lewy dots in ventral tegmental region of midbrain; d spongiform change in neocortex in temporal and limbic lobes; e CA2 sector of hippocampus with Lewy neurites; f CA2 sector of hippocampus with tau in subset of Lewy neurites; g, h cortical Lewy bodies in temporal neocortex; cortical Lewy bodies and Lewy neurites in temporal neocortex; i hippocampal CA2 neurites; j amygdala Lewy bodies and neurites; k ventral tegmental area Lewy neurites (“Lewy dots”); l substantia nigra pars compacta Lewy bodies.alpha-synuclein immunohistochemistry (b, c, e, h), phospho alpha-synuclein (i, j, k, l), tau immunohistochemistry (f), hematoxylin and eosin stain (d, g). Bar in b = 20 μm (applies to c, e, f, g, h, i, j, and k); bar in d and l = 50 μm; measure bar in a is in mm