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. 2018 Jun 15;9:2352. doi: 10.1038/s41467-018-04576-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — SBH-PACT of cancerous breasts. a X-ray mammograms of the affected breasts of seven breast cancer patients. LCC left cranial-caudal, LLM left lateral-medio, LML left mediolateral, LMLO left mediolateral-oblique, RCC right cranial-caudal, RML right medio-lateral. b Depth-encoded angiograms of the eight affected breasts acquired by SBH-PACT. Breast tumors are identified by white circles. For illustration, we marked the nipple of the first patient (P1) with a magenta circle. P1—48-year-old female patient with an invasive lobular carcinoma (grade 1/3); P2—70-year-old female patient with a ductal carcinoma in situ (microinvasion grade 3/3); P3—35-year-old female patient with two invasive ductal carcinomas (grade 3/3); P4—71-year-old female patient with an invasive ductal carcinoma (grade 3/3); P5—49-year-old woman with a stromal fibrosis or fibroadenoma; P6—69-year-old female patient with an invasive ductal carcinoma (grade 2/3); P7—44-year-old female patient with a fibroadenoma in the right breast and an invasive ductal carcinoma (grade 2/3) in the left breast. c Maximum amplitude projection (MAP) images of thick slices in sagittal planes marked by white dashed lines in b. d Automatic tumor detection on vessel density maps. Tumors are identified by green circles. Background images in gray scale are the MAP of vessels deeper than the nipple. e Maps of the relative area change during breathing in the regions outlined by blue dashed boxes in the angiographic images in d. The same tumors are identified by red circles. The elastographic study began with Patient 4, and it revealed all imaged tumors, including the undetected one in d (P7(L))