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. 2018 Jan 16;75(14):2591–2611. doi: 10.1007/s00018-018-2746-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 8 — Rescue of H3 phosphorylation, survivin, and ARKB with kinase-active murine VRK1. In U2OS cells, endogenous human VRK1was knocked-down with si-VRK1-02 and transfected with murine VRK1 (mVRK1) kinase active and inactive (mVRK1-K179E). Cells were treated with nocodazole for 13 h. The phosphorylations of histone H3-T3ph (a) and presence and localization of survivin (b) and ARKB (c) and the presence of H3-S10ph (d) determined by immunofluorescence, which represents their sequential order. Cells containing murine VRK1 were identified with an antibody against the myc epitope. The complete figure is shown as Supplementary Figure S7