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. 2018 Jun 15;8:9225. doi: 10.1038/s41598-018-27514-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR-10a-3p promotes the ossification of OPLL in vivo. (A) A scheme of the procedure in heterotopic bone formation assay. (B) Reconstructed 3D micro-CT images of the tissue-engineered bone constructs from different type of cells seeded (n = 6). The ratio of bone volume to tissue volume (BV/TV) and bone mineral density (BMD) of cultured bone constructs were shown in the right panel. *P < 0.05, **P < 0.01, t-test. (C) Reconstructed 3D micro-CT images of the tissue-engineered bone constructs that contains miR-10a-3p, miR-10a-5p or negative control stably expressed PLL cells (n = 6). The ratio of bone volume to tissue volume (BV/TV) and bone mineral density (BMD) of cultured bone constructs were shown in the right panel. **P < 0.01, t-test. (D) Reconstructed 3D micro-CT images of the tissue-engineered bone constructs that contains miR-10a-3p, miR-10a-5p or negative control stably inhibited OPLL cells (n = 6). The ratio of bone volume to tissue volume (BV/TV) and bone mineral density (BMD) of cultured bone constructs were shown in the right panel. **P < 0.01, t-test. The error bars represents ±S.D.