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. 2018 May 1;32(9-10):695–710. doi: 10.1101/gad.312850.118

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© 2018 Rawal et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — Model for cooperation between chromatin remodelers SWI/SNF and RSC in promoter nucleosome disassembly and repositioning at highly expressed genes. (A) At weakly expressed genes, relatively low levels of RSC (green oval) suffice to maintain wild-type NDR formation primarily by keeping nucleosomes (sectored cylinders) from crossing NDR boundaries. Cylinders with faint shades indicate nucleosome positions in cells depleted of functional RSC (Sth1). (B) Upon gene activation by Gcn4 or at highly expressed constitutive genes, SWI/SNF (red oval) and RSC are actively recruited and cooperate in evicting and repositioning the −1_Nuc and +1_Nuc to both widen the NDR and keep nucleosomes from assembling there. Cylinders with faint shades indicate nucleosome positions in cells lacking SWI/SNF or depleted of RSC. Pol II may also contribute to eviction of +1_Nucs.