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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Cancer Res. 2018 Apr 17;78(12):3163–3175. doi: 10.1158/0008-5472.CAN-17-3107

Figure 3. Combined inhibition of Wnt and Akt/mTOR results in synergistic inhibition of CRC cell proliferation.

Figure 3

A. HT29 cells were treated with the indicated inhibitors for 3 d. Cell proliferation was determined using the Vi-CELL XR 2.03 cell viability analyzer. B. HT29 cells were treated with the indicated inhibitors for 10 d. Colony formation was analyzed. C&D. LS174T (C) and primary human CRC cells (pt130) (D) were treated with the indicated inhibitors for 3 d. Cell proliferation was determined using the Vi-CELL XR 2.03 cell viability analyzer. (n=3, data represent mean ± SEM; *p<0.01 vs control; #p<0.01 vs single inhibitor). Data are from one of three independent experiments with similar results.