Skip to main content
. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Cancer Res. 2018 Apr 16;78(12):3233–3242. doi: 10.1158/0008-5472.CAN-16-1701

Figure 4. Adrenergic-mediated mTrkB activation leads to increased tumor growth and nerve counts.

Figure 4

(a) Tumor weight in restraint stress orthotopic SKOV3ip1 models treated with control or hTrkb siRNA-DOPC. (b) Nerve counts of tumors in each group in the hTrkb siRNA SKOV3ip1 model. (c) Tumor weight in restraint stress orthotopic SKOV3ip1 mouse models treated with control or mTrkB siRNA-chitosan. (d) Nerve counts of tumors in each group in the mTrkB siRNA SKOV3ip1 model. (e) Tumor weight in restraint stress +/+TrkBF616A mouse models treated with vehicle or 1NaPP1. (f) Nerve counts of tumors in each group in the ID8-VEGF tumor-bearing +/+TrkBF616A mouse model. Means and standard error of the mean are shown; n = 10 mice per group. *P < 0.05. Scale bar represents 50 μM.