Table 3.
The distribution of genotypes in T2DM cases and controls
| Model | Genotypes |
Patients
N(%) |
Controls
N (%) |
OR
(95% CI) |
P |
|---|---|---|---|---|---|
| rs1801214 | |||||
| Codominant | CC CT TT |
102 (45.9) 100 (45.0) 20 (9.0) |
78 (37) 96 (45.5) 37 (17.5) |
1.00 0.80 (0.53-1.20) 0.41 (0.22-0.77) |
0.016909 |
| Dominant | CC | 102 ( 45.9) | 150 (50.0) | 1.00 | 0.057837 |
| CT+TT | 120 (54.1) | 78 (37) | 0.69 (0.47-1.01) | ||
| Recessive | CC+CT | 202 ( 91.0) | 174 (82.5) | 1.00 | 0.008355 |
| TT | 20 (9.0) | 37 (17.5) | 0.47 (0.26– 0.83) | ||
| Overdominant | CC+TT | 122 ( 55.0) | 115 (54.5) | 1.00 | 0.924656 |
| CT | 100 (45.0) | 96 (45.5) | 0.98 (0.67–1.43) | ||
| log-Additive | - | - | - | 0.68 (0.52-0.91) | 0.007539 |
| rs1046320 | |||||
| Codominant | AA | 134 (60. 4) | 100 (48.5) | 1.00 | 0.030530 |
| AG | 73 (32.9) | 82 (39.8) | 0.66 (0.44- 1.00) | ||
| GG | 15 (6.8) | 24 (11.7) | 0.47 (0.23-0.93) | ||
| Dominant | AA | 134 (60.4) | 100 (48.5) | 1.00 | 0.014049 |
| AG+GG | 88 (39.6) | 106 (51.5) | 0.62 (0.42-0.91) | ||
| Recessive | AA+AG | 207(93.2) | 182 (88.3) | 1.00 | 0.078039 |
| GG | 15 (6.8) | 24(11.7) | 0.55 (0.28-1.08) | ||
| Overdominant | AA+GG | 149 (67.1) | 124 (60.2) | 1.00 | 0.136481 |
| AG | 73 (32.9) | 82 (39.8) | 0.74 (0.50-1.10) | ||
| log-Additive | - | - | - | 0.68 (0.50-0.91) | 0.008313 |
CI: confidence interval; N/A: not applicable; OR: odds ratio. P values for the most probable genetic models are indicated with bold face, and are statistically significant.