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. Author manuscript; available in PMC: 2018 Jun 17.
Published in final edited form as: Curr Opin Cell Biol. 2018 Apr 2;52:126–135. doi: 10.1016/j.ceb.2018.03.003

Figure 2.

Figure 2

Histone variant chaperones and pre-nucleosomal posttranslational modifications of CENP-A. (a) The interaction of histone H3 variants with distinct chaperone proteins determines the timing and site of variant nucleosome deposition. (b) The amino-terminus of prenucleosomal CENP-A is trimethylated and phosphorylated at Ser16/18. Recruitment of the HAT1 acetyltransferase through RbAp46/48 binding to CENP-A and histone H4 leads to acetylation of the histone H4 tail within the prenucleosomal complex.