Skip to main content
. Author manuscript; available in PMC: 2018 Jun 17.
Published in final edited form as: Curr Opin Cell Biol. 2018 Apr 2;52:126–135. doi: 10.1016/j.ceb.2018.03.003

Figure 4.

Figure 4

Role of the chromatin context in CENP-A deposition. (a) Histone H3 nucleosomes are interspersed within and surround CENP-A containing chromatin throughout the cell cycle (steady-state). H3 nucleosomes within CENP-A containing chromatin are enriched for H3 Lys4 and Lys36 dimethylation, and H3 Lys9 dimethylation marks are found in nucleosomes flanking centromeres. (b) During G1-phase, recruitment of the KAT7 acetyltransferase complex by the Mis18 complex facilitates histone H3 removal and the assembly of new CENP-A nucleosomes.