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. Author manuscript; available in PMC: 2018 Jun 17.
Published in final edited form as: Cancer Immunol Res. 2017 Nov 27;6(1):36–46. doi: 10.1158/2326-6066.CIR-17-0211

Figure 2.

Figure 2

Lengthening of the linker between variable domains in the GD2 CAR improves activity in vitro. A, Schematic of the GD2-XL CAR construct. B, Chromium release assay to measure specific cytotoxicity, performed as described for Fig. 1. GD2 CAR T cells or GD2-XL CAR T cells were incubated with the indicated targets (either GD2+ SY5Y or GD2low NB16), and nontransduced (NTD) T cells or CD19 CAR T cells were used as a negative control. Data show mean ± standard error of the mean (SEM) of three separate experiments using three different T-cell donors.