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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Horm Behav. 2018 May 12;102:76–84. doi: 10.1016/j.yhbeh.2018.05.002

Figure 2.

Figure 2

Effects of previous treatment with continuous, unopposed estradiol on hippocampus-dependent memory in ovariectomized mice. Mice were trained on the radial-arm maze, then ovariectomized and implanted with capsules delivering continuous treatment with estradiol (Previous Estradiol) or vehicle alone (Previous Vehicle). After 40 days all capsules were removed. Hippocampus-dependent memory was assayed during delay trials, in which various delays were inserted between the fourth and fifth arm choices, beginning 14 days after termination of treatment. (A) Mean number of errors of first 8 arm choices (±SEM) presented across delays. (B) Mean number of errors (±SEM) of first 8 arm choices averaged over all delays. *p<0.05 vs. Previous Vehicle.